There are lots of nanoparticles that have less toxic effects on the different cells of fish immune system. Nanoparticles have low cost as compared to the other materials in delivering of biological materials. Nanoparticles have gained much interest as a specific and sensitive tool for diagnosis of bacterial, fungal and viral diseases in aquaculture. There are different types of nanoparticles such as Cu based nanoparticles, sliver nanoparticles, metal oxides nanoparticles such as ZnO and TiO2 NPs, or composite of several metals. The applications of nanoparticles in aquaculture has promisingly seen in water quality improvement, aquatic animal nutrition, drug delivery, disease diagnosis and management but very few works and has been done in the greener approach as it is forming a new horizon in the aquaculture era. Silver nanoparticle are employed for the cleaning fresh water inhabiting fishes due to advanced cleaning system and special plates that cleans each drop of water in each direction of movement of water. By improving disease control, feeding formulation, and biofouling control, nanotechnology can improve aquaculture production and shrimp culture.