This study sought to establish the influence of economic factors on female students’ career choice in TVET science programmes in Siaya County, Kenya. The study was based on social Cognitive Theory. It adopted descriptive survey design. It is based on the conceptual framework whereby choice of careers in TVET by female students is assumed to depend on economic factors. Test- retest method was used to test reliability of the instruments. The research instruments were questionnaires. The sample size was 316 female students sampled using census method. Census, proportionate and simple random sampling techniques was used to sample respondents in different strata and TTIs. Tools in the Statistical Package for Social Sciences (SPSS) version 22 was used to analyze data. Frequencies, percentages and means were computed. Inferential statistics such as regression coefficients, T-statistics, F-statistics, correlation of coefficients shall were derived. Charts, graphs and tables were used to present the findings. Results indicated that there exists a negative and non-significant relationship between Economic Factors and Female Students’ Career Choice in Science TVET Programmes (r=-0.34; p>0.05). The significance of this study is that the findings could be used to come up with policies on how to increase the number of female students choosing careers in TVET. This could guarantee employment opportunities for women in the country which in turn could raise their standard of living.