This study was design to examine the acute toxicity of the 80% -ethanolic extract of CP Men capsules in healthy male and female Sprague-Dawley rats and phytochemical screening of the product. Six samples of the product were submitted to the Department of Pharmacology & Toxicology, School of Pharmacy, College of Heath Sciences, University of Ghana, Legon, Accra for the analysis and others. The investigators at the University declared in their research report that the study was conducted at the Animal Experimentation Unit of the School of Biomedical and Allied Health Sciences (SBAHS). College of Health Sciences, university of Ghana. On clinical Observation, the study conducted reports that the animals treated by the ethanolic extract of CP Men capsules (5000 mg/kg) did not show any observable abnormality in movement, salivation, sleep, lethargy, there was no signs of piloerection and mortality in comparison to the control group within the first 48 hours, and daily during the 14 days of the study. With regards to Lethal Dose Fifty (LD50), the study found that per monitoring the animals for 24, 48 hours and throughout the remaining 12 days, the group of rats treated by the ethanolic extract of CP Men capsules did not record any deaths. Hence, the LD50 of the ethanolic extract of CP Men capsules, when administered orally, is greater than 5000mg/kg. In conclusion, further studies involving long term administration of aqueous extract of CP Men capsules in different experimental rodents, including mice, will be needed to assess its safety for trial and use in humans. More renal function markers such as creatinine should be analyzed. The phytochemical screening also demonstrates that the herbal drug is of plant origin.