Coronavirus Disease 2019 (COVID-19) is the third life-threatening pandemic disease. It started in December 2019 in Wuhan, China. Cases of SARS-CoV-2 infection may be asymptomatic or have a range of symptoms with the most common being fever, cough, and shortness of breath. Correct clinical laboratory analyses which give results in a well-timed or prompt manner are critical for the clinical and public health administration of COVID-19. The clinical presentation and stage of the COVID-19 disease determine the option as to which laboratory analysis to apply for the diagnosis. The application of the real-time reverse transcriptase-polymerase chain reaction (real-time RT-PCR), for nucleic acid analyses, is the most correct method for diagnosing acute SARS CoV-2 infection. The ideal specimen types are combined deep nasal or nasopharyngeal and throat swabs. Application of serology can be performed for the diagnosis of a previous infection that is more than 14 days after the beginning of clinical features. Antigen analyses are also carried out in most developed countries. The analytical results interpretation must take into consideration the pre-test likelihood or possibility of the patient having COVID-19 disease.