Ascariasis is an infection of the small intestine caused by Ascaris lumbricoides. The aim of this study was to evaluate the medicinal potency of lime (Citrus aurantifolia) juice and ogogoro (Local gin) mixture on ascariasis as well as assessing its effects on hepato-renal and inflammatory biomarkers. Thirty primary school children whose stool samples upon microscopical examination at x40 were found to have 2+ ova of Ascaris lumbricoides (experimental group) and another thirty whose stool samples had no ova of Ascaris lumbricoides (control group) were recruited for this study. Each of the subjects in the experimental group was administered orally with ten milliliters of the mixture twice daily for five consecutive days. Two weeks after the completion of this oral administration, their stool samples were re-examined microscopically using x40 objective and it revealed 70% significant therapeutic response to Ascaris lumbricoides i.e. zero ova. Thereafter, five milliliters of blood specimens were collected into lithium heparin anti-coagulated bottles from each subject in the control and experimental groups respectively. These specimens were spun and the obtained plasma used for the quantitative measurement of hepato-renal and inflammatory biomarkers which revealed no statistically significant differences (p>0.05) when compared. In conclusion, this study has given an insight on the medicinal potency of this mixture in the treatment of ascariasis and its use is therefore recommended.