Angiogenesis is a complex, sophisticated process, subjected to many different conditions. A number of basic mechanisms of angiogenesis have been deciphered and several targets for therapeutic intervention have been identified. In recent decades, numerous pro and antiangiogenic molecules, as well as their ligands and intracellular signaling pathways, have been identified for treating numerous diseases. For the past decades angiogenesis has been a field under extensive investigation. Tumours depend on the growth of a vascular network, which is stimulated by a variety of angiogenic mediators, providing them with blood and oxygen. Inhibition of these factors and its pathways, there by reducing the growth of blood vessels was major breakthrough in treatment of cancer. Even though anti-angiogenic therapy has gained a lot of progression in the past decade, combination of conventional methods like chemotherapy and radiotherapy along with the antiangiogenic therapy would be more beneficial to the patient. This is a review article to understand the mechanism of action and clinical significance of angiogenesis.