Background: Cervical cancer ranks as the fourth most frequently diagnosed cancer and the fourth leading cause of cancer death in women. Almost 70% of the global burden of cervical cancer falls in areas with lower levels development, and more than one-fifth of all new cases are diagnosed in India. Cancer cervix has been considered preventable because it has a long pre-invasive state and availability of screening programs and treatment of pre- invasive lesion is effective. No form of cancer documents the remarkable effects of screening, early diagnosis and curative therapy on mortality rate in a better way than does cancer cervix. Aim: To compare the diagnostic value of Visual Inspection of Cervix with Acetic Acid with Papsmear for screening of Cervical intraepithelial lesions keeping Histopathology as gold standard. Material and Method: It is a cross sectional and comparative study of 522 women who fulfilled inclusion criteria attending outpatient Department of Obstetrics and Gynaecology at St Philomena’s Hospital for a period of 2 years (December 2016 to November 2018). Both pap smear and VIA are done in these cases. In positive cases, colposcopy guided cervical biopsy done and sent for histopathological studies. All results compiled and analyzed. Sensitivity, specificity, positive predictive value and negative predictive value are calculated and compared for pap smear, visual inspection with acetic acid by taking colposcopy guided cervical biopsy (histopathology) results as gold standard. Result and observations: In the present study , diagnostic values of VIA are comparable with papsmear with sensitivity of 86.6% and 80.6% respectively, specificity of 97.8% and 98.9% respectively, PPV of 85.3% and 91.5 % respectively and NPV of 98% and 97.2% respectively with histopathology as the gold standard. Conclusion: VIA has comparable results to Pap smear regarding its sensitivity, specificity, positive predictive value and negative predictive value and can be used as good alternative to pap smear in mass screening of large population. VIA can be combined with Pap smear to improve the efficacy of screening procedures in detection of pre-cancerous and cancerous lesions of cervix.