Aim: The aim of our study was to assess and observe the changes in Maximum von Mises stresses in relation to force application during miniscrew placement at two different insertion angles in proximity of PDL under varying magnitudes of load and locations. Methods: Patient specific finite element models of the area of interest involving maxillary 1st molar and 2nd premolar were developed using computed tomography images. An Miniscrew implant surface model derived from micro-computed tomography was placed at three different levels away at regular intervals from the PDL of the premolar. Finite element analysis was conducted with 45 and 90-degree angle on the MSI, with a loading force of 100g and 200g, at a distance of 1mm,1.5mm and 2.0mm from the PDL. Maximum von Mises stresses was calculated at each distance. To explain compressive stress by proximity, load magnitude and different insertion angle stepwise multiple regression models was conducted. Results: The multiple regression models explained the variation of MPa and included all three factors: proximity, load magnitude and angulation. The regression model showed significant interaction between the three factors, proving that lesser angulation & load magnitude and implant position far away from the 2nd premolar PDL could be associated with minimal amount of stresses generated and decreased effect on roots. Conclusion: To safeguard the adjacent roots and periodontal ligament structures the MSI should be placed at 90-degree angulation, with a loading force of 100g and at 2mm from the 2nd premolar’s PDL to produce minimum compressive stresses.