According to Sangiuolo, there are two main methods of replacing the denture base: the first is called relining and the second is called rebasing. Indeed, the term rebasing is defined as, “A process of refitting a denture by the replacement of the denture base material by preserving the same prosthetic teeth“. The main purpose is to re-establish adequate adaptation of the denture base to the bearing area and to preserve the original jaw relations. This technique is mainly indicated in the case of an immediate or late static prosthetic instability induced by physiological or pathological resorption. The approach is the same as the final impression with the obligation to have a well-balanced occlusion with a correct occlusal plane, a valid centric relation with the right vertical dimension. This manuscript attempts to cover most of the common complete denture rebasing indications along with a simple description of clinical and laboratory steps that can any practitioner follow to succeed the prostheses base replacement.