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Saudi Journal of Pathology and Microbiology (SJPM)
Volume-2 | Issue-04 | 111-114
Original Research Article
Medullary Aplasia in the Child: Epidemiological, Clinical and Biological Aspects in the Hematology Laboratory of CHU Hassan II of Fez
Dr. Amadou Djibrilla, Pr. Imane Tlamcani, Dr. Imane Jamai, Dr. Boubacar S. Marou, Dr. Nazik El. Hammouni, Pr. Moncef Amrani, Dr. Boubacar Efared, Pr. Hinde El Fatemi
Published : April 28, 2017
DOI : 10.21276/sjpm
Abstract
Medullary aplasia (MA) is a rare and severe affection. It is much rarer in children. The etiologies are multiple: constitutional, acquired, and idiopathic. In order to evaluate the epidemiological, clinical and biological aspects of bone marrow aplasia in a pediatric population, we carried out a retrospective study of 9 cases collected in the hematology department in collaboration with the department of anatomy pathology of the Hassan II CHU in Fez over a four-year period from January 2013 to December 2016. Age ranged between 1 and 14 years, with a sex ratio of 3.5. The anemic, hemorrhagic and infectious syndrome was noted respectively in: 9, 7, and 6 cases. The hemoglobin varied between 3.3 and 7.3 g/dl with an average of 5 g/dl, anemia is normochrome normocytic argenerative in all our patients. Neutropenia was found in 100% of patients, and all patients had thrombocytopenia with platelet counts ranging from 500 to 105000/mm3. The BOM-coupled myelogram was performed in all patients, confirming the diagnosis of AM. For the etiologies, Fanconi Anemia was evoked in 4 cases and idiopathic in 5 patients.
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