Wetlands play significant role in climate change contributing about 5% of the global Carbon dioxide (CO2) emission through respiration which is being thought to be influenced by the soil properties. In this study the aim is to establishing relationship between wetland soil physicochemical properties and CO2 respiration from Oguta lake point one. Standard methods were used to determine the soil properties and an AZ 77535 CO2 gas analyzer held at arm’s length was used to determine the concentration of CO2 at sample location. Mean results showed pH (5.03), temperature (28.16 oC), electrical conductivity (108.56 uS/cm), moisture content (17.83 %) and organic matter (1.35 %). Mean weekly [CO2] concentrations (564 ± 13.5 to 580.72.2 ± 13.03 ppm) were higher than mean around the world (370 ppm) and higher all sites around the lake including the control site (425 ± 2.5 to 438.2 ± 2.0 ppm). There was positive relationship with [CO2] and R2 values of (0.262), (0.370), (0.304), (0.294) and (0.056) respectively were observed. This confirms that the respiration of CO2 is influenced by the soil properties. An increase in soil properties reflected an increase CO2 concentration. Results add to information on how soil properties can be modified to reduce soil respired CO2, thereby reducing wetland contributions to global warming.