Amino acids are molecules containing an amine group; a carboxylic acid group and aside chain that varies between different amino acids. These molecules are particularly important in biochemistry, Amino acids containing uncharged amino groups, at physiological PH values, may also undergo Schiff base formation, which presents another potential mechanism for metal complexes. In this study, four new amino acid Schiff base compounds namely; 5-Chlorosalcialdehyde-glycine (H2L1), 5-Chlorosalycialdehyde-alanine (H2L2), 5-Nitrosalycialdehyde-glycine (H2L3), 5-Nitrosalycialdehyde-alanine (H2L4). Derived from condensation reaction of substitutedsalicylaldehyde with some amino acids; glycine and α-alanine, with a new alternative method. The development includes the use of 10-2mole sodium hydroxide as a new catalyst, which is added to the classical method of Schiff bases synthesis. The four Schiff bases were characterized by elemental analysis (C.H.N) and spectroscopic methods; IR, 1H and 13C NMR. These methods were applied successfully for characterization of the prepared Schiff bases.