Objective: To study the role of IgM enriched IVIg in reducing mortality in neonatal sepsis. Method: It is a prospective randomized study conducted in Special Newborn Care Unit(SNCU) of CNMCH, Kolkata over a period of two years (June 2016 – May 2018).Two groups of 248 newborn each (matched for gestational age, sex, weight and other variables) were randomly allocated to receive either antibiotics alone (control group) and antibiotics plus IgM enriched IVIg intravenously (5ml/kg/day) for 4 days(Immunotherapy Group). Result: Mortality from sepsis in control group was 88/248 (35.5%) of which death from culture proven sepsis was 70/182 (38.5%) and culture negative sepsis was 18/66 (27.3%).In immunotherapy group overall mortality was 40/248(16.1%) of which death from culture proven sepsis was 32/192 (16.7 %) and culture negative sepsis was 8/56(14.2%).Conclusion: We conclude that IgM enriched IVIg therapy in conjuction with antibiotic significantly reduces mortality in neontal sepsis,particularly in culture positive cases.