Colorectal diseases are frequently encountered in clinical practice. They range from minor problems causing minimal discomfort to potentially serious diseases causing much morbidity and mortality. Clinically most of these disorders present with non-specific symptoms like altered bowel habits, diarrhea, bleeding per rectum either melaena or fresh hemorrhage; thus causing much delay in drawing attention. Early detection and proper management are essential to reduce the morbidity and mortality. Various diagnostic tools are developed in the recent past, improving the detection and assessment of these lesions. To study the profile of various neoplastic colorectal lesions and to know the relative frequency of various diseases, and to know the age, sex incidence and site of occurrence of the neoplastic colorectal lesions. This study was carried out in the Department of Pathology, NRI Medical College, Chinakakani, Guntur district.