Background: The outbreak of Covid-19 is a new but one of the most intense pandemics in the world now. Although this disease is accountable for limited symptoms and complications like severe acute respiratory syndrome, fever, headache, diarrhea, malaise, and weakness, its probability of affecting people is very high. For this reason, its psychological and socio-economic impact demanded more attention from the world community. Aim of the study: The aim of this study was to evaluate the psychological and socio-economic impact of Covid 19 among the OPD patients in a tertiary care hospital in Bangladesh. Methods: This was a prospective interview-based study conducted in the Department of Medicine, Ibn Sina Specialized Hospital, and Dhaka, Bangladesh during the period from July 2020 to December 2020. In total 120 patients with several health problems, physically or virtually attended the OPD of the mentioned hospital were enrolled as the study population. The ethical committee of the mentioned hospital had been approved the studyl. All data were processed, analyzed, and disseminated by MS Office and SPSS version as needed. Result: In this study analyzing the negative impact of Covid 19 on the mental health of participants, we found feeling of suffocation, exhaustion, fear of falling ill, anxiety about the future, and feeling of loneliness were found as some major negative mental impacts on the respondents which were 11.67%, 10.83%, 8.33%, 7.5%, and 6.67%. Besides these, due to Covid 19 continuing, remote socialization, intolerance to others, random commitment violation, and ended social life were found 10%, 5.83%, 4.17%, and 1.67% participants respectively. In analyzing the negative impact on the economy of participants, we observed, the monthly family income was decreased up to 25%, 50%, 75%, and 100% of 21.67%, 12.50%, 5%, and 1.67% participants respectively. That means negative impact like decreasing monthly family income was found around 49%. Conclusion: Pandemic of Covid 19 is a new experience for the world community. The psychological and socio-economic impact of Covid 19 among patients as well as general people demanded more concentration now. Besides general people and patients, the whole economy and social structure of Bangladesh have already been affected by COVID-19. Unemployment and uncertainty of family income are responsible for secondary negative impact on the mental, physical health of general people as well as patients here. So, government policymakers, as well as world leaders, should be more conscious about these impacts and find out the proper way to resolve such pandemic.