Hidradenitis suppurativa (HS) is a chronic and painful skin disease. In addition, HS lesions may be associated with pus and odor, potentially leading to significant stigma. Our patient is a 33 year old single man with previous diagnosis of hidradenitis suppurativa since childhood and now is suffering from depression and anxiety. The patient mention follow clonazepam and cigarette use his discharge are declined. As role of stress and anxiety in inflammation, it is possible that benzodiazepine drug and cigarette smoking reduce inflammation and related secretion.