Background: Post-operative patient outcome of Manual Small Incision Cataract Surgery (MSICS) and Phacoemulsification (Phaco) should focus on functional status and quality of life instead of only visual acuity measurement alone. Aim: Comparative study to evaluate functional outcome of quality of life in post-operative patients of Manual Small Incision Cataract Surgery (MSICS) vs Phacoemulsification (Phaco) using Indian visual Function Questionnaire-33. Design: A prospective, comparative hospital based interventional study was conducted on 246 eyes having visually significant senile cataract. 246 eyes were divided into two groups. 123 eyes were planned for MSICS & Phacoemulsification each at Regional Institute of Ophthalmology, Pt.B.D.Sharma PGIMS, Rohtak. A detailed pre and post-operative examination was carried out and interviewed as per IND VFQ-33 questionnaire pre-operatively and post-operatively at 1 week, 1 month and 2 months. Results: There was a significant difference between 2 groups in terms of Quality of Life Scores at Post-Operative Day-7.With the median QoL Score (Domain 1+2+3) at Post-Operative Day-7 being highest (87) in the SICS group as compared to Phacoemulsification (74) with p<0.001.There was no significant difference between 2 groups in terms of VR QoL Scores at Post-Operative 1 & 2 Months. Median Quality of Life Score of (Domain 1+2+3) at 1 Month was 57 in both study groups with p=0.808. Median Quality of Life Score (Domain 1+2+3) at 2 Months was 43 in both MSICS & Phacoemulsification group with p=0.636. Conclusions: The study group patients observed no difference in terms of Related Quality of Life in post-operative Manual Small Incision Cataract Surgery and Phacoemulsification especially after 1 & 2 months. So functionally, quality of life in post-operative 1-2 months of Manual Small Incision Cataract Surgery and Phacoemulsification are equally good.