Objectives: To provide an update regarding the recent trends and advancements in the field of salivary nano-biosensors which are useful in diagnosis of oral squamous cell carcinoma? Materials and methods: Literature survey was carried out in March 2021 in electronic databases such as PubMed SCOPUS, EMBASE, COCHRANRE library, Science Direct using key words such as Biosensors and oral cancer, Salivary biosensors and oral squamous cell carcinoma etc... Articles published in English language from 2000 to March 2021 which fulfilled the objectives of the study were included. Results: The searches revealed 236 articles out of which 42 were selected after reading the full text articles. Saliva based diagnostics is also referred as liquid biopsy for its immense potential as it is economical, noninvasive and easy to collect and contains wide variety of biomarkers which can be detected by biosensors. The use of biosensors in oral cancer detection and monitoring holds vast potential. Biosensors can be designed to detect emerging cancer biomarkers and to determine staging of the disease and diagnosis. Even though there are wide varieties of biomarkers, only few biosensors have the potential to become point of care diagnostics of oral cancer. Conclusions: The technological advancements in recent times have enabled researchers to develop high throughput and sensitive biosensors to detect active biomarkers from saliva of oral cancer patients.