vital not only to provide comprehensive care but also to enhance and promote competence. This study is a comparison between a general and a specialized hospital. Objectives: Measure knowledge, and skills among nurses in two different hospitals. Methods: A cross sectional survey questionnaire used for collecting data, 60 nurses from each hospital. Statistical analysis: Descriptive statistics, chi-square test used to compute association among variables, the p-value of <0.05 was considered as statistically different. Result: There is no difference in skills and knowledge in most procedures except for some specific procedures. In addition, the load of work varies from hospital to others. Conclusion: Nursing, in both hospitals; showed having the required level skills and knowledge. However, continuous cross training directed to enhance some specific nursing procedures, regardless of the working hospital.