This is a quasi-experimental study to determine the internal administration of Acalypha indica leaves powder in management of cough. Cough is a natural reflex expulsive defense mechanism of the body, for clearing excess secretions or mucous or inhaled irritants or toxins or foreign substance in the respiratory tract it is the commonest symptom of respiratory diseases. Productive cough means a sudden, noisy expulsion of air from the lungs that effectively removes sputum from the respiratory tract and helps clear the airways, permitting air to reach the alveoli. The treatment of coughs is one area where the use of certain herbal remedies remains common today. In the Siddha system Acalypha indica herb is considered to be effective medicine for cough. This is an annual herb belongs to Family Euphorbiaceae. The researcher administered questionnaire was used to collect data. Fifty (50) clinically diagnosed productive cough patients were randomly selected at District Siddha Ayurveda Hospital, Kopalapura and symptoms were evaluated based on scoring system. Evaluation visit were made baseline on 7th, 14th, 21st , 40th day interval, after final assessment were observed after one week for getting information about recurrence of disease. The effect of treatment was evaluated on basis of changes of degree of symptoms after treatment.Statically highly significant improvement (p<0.000) in reduce of bouts of cough, sputum expulsion, throat irritation and nasal discharge.