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Scholars International Journal of Obstetrics and Gynecology (SIJOG)
Volume-4 | Issue-04 | 143-148
Original Research Article
AMH (Anti- Mullerian Hormone) in Relation to High FSH (Follicle Stimulating Hormone) in Female Subfertility: A Cross Sectional Analysis
Dr. Rupa Shamima Bashar, Dr. Shakeela Ishrat, Dr. Rolly Suriya Jahan, Dr. Marufa Hossain, Dr. Muhammad Jasimuddin, Dr. Sheikh Farhana Huda
Published : April 21, 2021
DOI : 10.36348/sijog.2021.v04i04.011
Abstract
Background: Aged women who have infrequent menstruation and raised FSH are likely to have diminished ovarian reserve. Serum AMH is a novel marker of ovarian reserve but the test is expensive. The objective of this study is to determine serum AMH level in women who have high FSH and see how AMH and FSH correlate in this group of women. Methods: We did an observational cross sectional study of 87 infertile women, age 30-39 years, with oligomenorrhoea and high FSH (>10IU/L). Serum FSH was measured on day 2-4 and AMH was measured on any day of menstrual cycle. The women were divided into three groups based on FSH: 10-20 mIU/mL, 21-40 mIU/mL and >40 mIU/mL. Correlation of AMH with FSH was analyzed in all participants as well as within different groups. Results: The mean serum FSH D(2-4) was found 38.8±22.4 mIU/ml, range (min-max) (10.2-93.5) mIU/mL. Not all but 85.1% women had low (≤1.0 ng/ml) serum AMH level. Mean serum AMH was 0.74±0.59 ng/mL, range (min-max) (0.90-2.9 ng/ml). The serum AMH decreased in groups with higher FSH. The one way ANOVA shows that there is significant difference in AMH values between the groups. There is moderate (r = -- 0.537) negative correlation of AMH with FSH. The negative correlation of AMH with FSH is strongest (r = - 0.735) in the group having FSH in the range 10-20mIU/mL. The correlation is comparatively less (r = - 0.519, r = - 0.616) in groups with higher FSH. Conclusion: Not all the sub-fertile women with infrequent menstruation and FSH>10 mIU/mL have lower AMH (<1 mg/ml). A significant negative moderate correlation exist between AMH and FSH. The correlation is relatively stronger in the FSH range 10-20 mIU/mL.
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