Thyroid diseases are a common endocrine disorder, and thyroid hormones physiologically are well-known to have direct and indirect effects on metabolic abnormalities. Disorders of carbohydrates (glucose) metabolism are frequently reported in both hypothyroidism and hyperthyroidism. This review considered to examine and analyze the role of thyroid hormones and their abnormalities in different level of glucose metabolism in intestinal and liver cells. A broad literature search been performed on Google Scholar and PubMed for the periods between 01/01/2021 and 25/03/2021. The search includes the followings key words; thyroid hormones, glucose metabolism, hepatocytes, hypothyroidism, hyperthyroidism, thyroid receptors. Liver represents a major organ that involves in both consumption, storage and production of glucose. The expression of thyroid hormones receptors in the hepatocytes are often recoded. Thyroid hormones facilitate glucose absorption from gastrointestinal system. In hyperthyroidism, hepatic glucose intake, glucokinase activity, mitochondrial activity and biogenesis, gluconeogenesis, glycogenolysis and hepatic glucose production all shown to increase. In hypothyroidism, intestinal Glucose Absorption, GLUT2 expression in hepatocytes, hepatic glucose intake, glucokinase activity, mitochondrial activity and biogenesis, gluconeogenesis, glycogenolysis are all seeming to reduced. In conclusion; Thyroid hormones represents a major regulator of glucose metabolism, and achieve their effects through promotion or demotion of expression or activation of enzymes responsible for regulation of different metabolic pathways. Thyroid disorders is associated with abnormal metabolism that could disturb the metabolic pathways and contributes or exacerbate other concomitant disease such as diabetes and metabolic syndrome.