In the body with the high specificity and the sensitivity the ability of to detect the physiological and the pathogenic related molecules offers a opportunity which is very powerful and helpful in the treatment of the disease with the early diagnosis. The optical base biosensor in which the optical fiber cable is used in the different research and in many other medical fields. Bacteriophages are ubiquitous viruses, found wherever bacteria exist. It is estimated there are more than 1031 bacteriophages on the planet, more than every other organism on earth, including bacteria, combined. In recent years it has become widely recognized that bacteriophages have several potential applications in the food industry. They have been proposed as alternatives to antibiotics in animal health, as biopreservatives in food and as tools for detecting pathogenic bacteria throughout the food chain. Phages play a key role in maintaining microbial balance in every ecosystem where bacteria exist, and they are part of the normal microflora of all fresh, unprocessed foods. Interest in various practical applications of bacteriophages has been gaining momentum recently, with perhaps the most attention focused on using them to improve food safety.