Primary neuroendocrine carcinomas of the breast (NEBC) represent a rare subtype of breast cancer, accounting for 2-5%. They generally present a more aggressive clinical form with a strong tendency to local and distant recurrence compared to other types of invasive breast carcinoma and they do not present specific clinical or radiological characteristics. We report the case study of a 58 years old female patient with primary neuroendocrine carcinoma of the breast.