Background: ACS is a major cause of mortality and morbidity in both developed and developing countries. HsCRP is an independent risk marker of cardiovascular disease. Objective: The aim of this study was to compare serum hsCRP levels and lipid profile and to correlate with angiographic findings. Materials and methods: This is a case control study, 70 patients with onset of chest pain and 70 sex matched controls were enrolled. Details of clinical examination, ECG, angiographic findings and laboratory findings like CK-MB, AST, LDH also collected. RESULTS: Among the cases, highest mean levels of hs-CRP, CK-MB and LDH were found in STEMI patients compared to other two groups. Among the 28 UA patients 21 were diabetic (75%), in the case of STEMI it was 79%, 19 out of 24, and in the case of NSTEMI 12 out 18 (67%). Patients with SVD, had hs-CRP levels <1-3 mg/L whereas most of the patients with TVD had elevated (>3 mg/L) hs-CRP level. Conclusion: The present study showed a positive correlation between hsCRP, dyslipidemia and angiographic findings in ACS. Hs-CRP seems to be a stronger predictor of cardio vascular events.