Bridelia ferruginea is commonly grown in Western Tropical Africa. The purpose of this research work is to determine the antimicrobial activities, qualitative and quantitative phytochemical screening, elemental composition, proximate analysis and anti-nutrient composition of purified fraction of Bridelia ferruginea extracts. The organisms used for this research are Staphylococcus aureus ATCC 29213, Escherichia coli ATCC 25922, Klebsiella pneumonia ATCC 35659, Pseudomonas aeruginosaATCC 25619,and candida albican ATCC 90029. The leaf and bark were extracted using ethyl acetate as the extracting solvent. The plant extracts were partially purified using Colum chromatography method of analysis, to separate the plant extracts to different fractions and various eluting solvent namely N-hexane, ethyl acetate and ethanol were used during Colum chromatograph. The antimicrobial activity of partially purified fractions Bridelia ferruginea were determined by agar dilution method. The result revealed that fraction of ethyl acetate extracts of Bridelia ferruginea leaf and bark eluting with N- hexane, ethyl acetate and ethanol were effective against some of the clinical isolates. In fraction one (f1), fraction two (f2) and fraction three (f3) of purified ethyl acetate leaf extracts, using ethanol, ethyl acetate and n-hexane as the eluting solvent.