It is well known that nurses are the largest manpower in healthcare delivery system of any country. Though, they spend sleepless nights in caring and curing the sick one but continuously striving for professional honour and dignity what they actually deserve. Instead of getting recognition, respect and reward, this profession face exploitation, struggle for existence, discrimination, humiliation from their own persons and even from medical colleagues. There is a negative portrayal of this professional image as feminine, menial, subservient roles with low intellect, taken for granted and assistance of physician only. The term “Oppression” has been described for nurses who represent powerlessness, submissiveness and domination. Nurse leaders often talks about qualities of self-esteem, assertiveness, accountability, control over practice, self-advocacy and autonomy but in contrary nurses in below hierarchy reported higher levels of dominancy, lack of initiative and fear of retaliation. Negative consequences of oppression resultant decreased workforce performance, dissatisfaction, self-hatred behaviour, submissive aggressive syndrome, horizontal and lateral violence, workplace bullying and poor retention of nurses in the same workplace. Therefore, this article is aimed to pinpoint & bring insight on those major challenges faced by nurses due to oppression and propose remedial strategies to reshape and uplift this profession as a prestigious one.