Eye is a special sensory organ which exhibits diverse histological structures. It shows wide spectrum of pathologies ranging from trauma, degenerative, inflammatory, and neoplastic conditions. So this study was done to determine the pattern and proportion of different ophthalmic lesions in hospital. Total 95 biopsies and specimens of orbito-ocular lesions were received and were examined after H & E staining and immunohistochemistry was applied whenever required. This study was carried out in the Department of Pathology, SMS Medical College, Jaipur, for the duration of 1 year. It was found that females 50 (52.63%) were more commonly affected than male 45 (47.36%) with male to female ratio of 0.9: 1. The orbito-ocular lesions were highest 20 (21.05%) in age group of 0-10 years. The lesions were categorised as Non-neoplastic 7 (7.36%), Benign 40 (42.10%) and Malignant 48 (50.52%). Eyelid 48 (50.52%) was the most commonly involved site followed by conjunctiva, and was the significant finding. Most common benign lesion was epidermoid cyst 10 (25%). Among malignant lesions squamous cell carcinoma 12 (25%) was most common. Retinoblastoma was the commonest intraocular malignancy in paediatric age group. All surgically resected ophthalmic lesions should always be subjected to histopathological examination to establish the accurate diagnosis for further management.