Corona Virus has become a huge cause of burnout and frustration among common public in general and among healthcare staff in particular. In some situations healthcare workers are not even able to express their fears, thoughts and experiences. Level of anxiety, depression and physical stress is increasing in health care staff, especially in nurses because of multiple factors. This review article will highlight challenges faced by nurses and other health care staff while caring for patients in COVID-19 isolation wards. Furthermore, through this paper readers will be able to find out some coping strategies to fight with commonly occurring issues during COVID-19 pandemic. Past studies will be presented as literature review to ensure the authenticity and enrichment of content.