Family caregivers of individuals with serious mental illness (SMI) play an essential role in managing patient conditions. The shift towards community care for patients has resulted in transferring patient care to family members, resulting in significant challenges. Studies have documented the experiences of family caregivers in Western countries. However, a clear overview of family caregiver experiences of persons with SMI in non-Western countries is warranted. The purpose of this study was to integrate and summarize the current literature about family caregiver experiences in non-Western countries. Five databases were searched using relevant keywords for studies published in English from 2015 to 2020. The studies included in the review were qualitative and quantitative designs, representing several non-Western countries. This systematic review included 25 articles and data synthesized based on similarities and different findings. The findings of this systematic review will provide more knowledge on the experiences of family caregivers of persons with SMI in non-Western countries, including burden, coping, psychological well-being, and stigma. This review found that additional research is necessary to understand the family caregiver experience and how healthcare teams can support caregivers. Further, the findings may help to inform health care policymakers to tailor strategies that support family caregivers.