Background: Nurses are the frontline healthcare workers and during the current pandemic COVID-19, they are at increased risk. Considering their work patterns and the pressure of the work, they experience stress. There is very little data available regarding the incidence of stress among nurses during this pandemic. Methods: This was a cross-sectional study which was done at Security Forces Hospital, Riyadh, Kingdom of Saudi Arabia. The objective of this study was to examine the presence of stress among nurses working in a tertiary care hospital. We calculated the sample size as 57. We used the Perceived stress scale (PSS) in our study. We gave the questionnaire comprising PSS questions to nurses from different wards. We calculated the mean, standard deviation, frequency count, and percentages for the perceived stress. Results: The mean PSS-10 score was 20.8 (SD: 4.61) with a range between 11 and 29. Two (3.3 %) nurses had low stress and 52 (86.7 %) nurses had moderate stress while 6 (10 %) nurses had high stress. Conclusion: The majority of nurses in our study experienced a moderate level of stress during this COVID-19 pandemic.