Rheumatoid arthritis is chronic rheumatism characterized by symmetric, inflammatory, peripheral polyarthritis with a highly destructive potential. Systemic lupus erythematosus is a multi-system autoimmune disease that combines visceral involvement with very frequent and disabling joint damage. These two pathologies share many clinical manifestations and may coexist in a patient. Such condition defines the Rhupus syndrome, which is a rare overlapping syndrome. The exact etiopathogenesis remains unknown. Serious visceral damages, particularly renal, are exceptionally reported during Rhupus syndrome. We report the case of a male patient diagnosed with Rhupus syndrome who presented with glomerulonephritis.