SS homozygotic sickle cell disease combines chronic hemolytic anemia with vaso-occlusive and infectious complications. The association between Sickle cell disease and pregnancy is a maternal and fetal high-risk situation. Case description: A 27-year-old woman carrying a pregnancy on a sickle cell field with a history of miscarriage and hospitalization in critical care department for post-abortion septic shock. Her pregnancy was followed in our department in collaboration with internists, under aspegic, acfol and tardyferon and during the pregnancy, she received three blood transfusions and a caesarean section was planned at 39 weeks of gestation. She gave birth to a newborn weighing 3600g in good condition. The post-partum was marked by a fortuitous discovery of IVC thrombosis. Conclusion: Sickle cell disease and pregnancy is a high-risk situation as we illustrate in our case. In addition to the absence of complications during pregnancy, post-partum also remains a period of risk even without obvious clinical manifestation