Pediculus humanus has always been the most obstinate ectoparasites that evolved with human beings and persist till today throughout the world. These wingless nemeses are extremely hard to deal with, because they prefer the human body temperature for their existence and propagation or reproduction. Numerous studies have been conducted to exterminate these blood feeders by the employment of several natural as well as synthetic regimens but not with an ideal proficiency. Anyhow, a multifaceted product would be beneficial for killing and removing the lice and their stubborn nits from the human hair shafts permanently. Our current focus is to introduce an all rounder treatment with a marvellous fusion of deltamethrin (DMT) and diisopropylfluorophosphate (DFP) along with dimeticone (PDMS). The tonic lotion with the amalgamation of aforementioned antilice candidates will stop lice reproduction, accessory gland secretions that are mediated by corpora allata, nit formation, neurotransmission and behavioural responses which will ultimately lead to clearance of these hematophagous insects. So as there is no promising solution to this global discomfort at present, our novel proposal will hopefully pave a new way to eradicate lice forever.