Mycetoma is a chronic, suppurative, granulomatous infection of subcutaneous tissue that eventually may involve bone. The Infection is caused by free living, exogenous, geophilic actinomycetes and fungi. It is characterized by a triad of localized swelling, underlying sinus tract and production of grains or granules. Approximately 40% of mycetomas worldwide are eumycotic and rest is actinomycotic [1]. Eumycetoma is most probably acquired by traumatic inoculation of certain fungi into subcutaneous tissue. Fungi are considered as an unusual cause of osteomyelitis of hand/palm. This paper describes a case of eumycetoma osteomyelitis of the hand. With clinical, radiological and pathological correlation we arrived at a final diagnosis.