Oral Lichen planus is a mucocutaneous disease of autoimmune origin having a prevalence of 0.02 percent in India and affecting women more [1]. It is a perplexing condition and poses dilemma to the dentist in providing the apt treatment to the patient. Though various treatment modalities are available steroids is the most commonly prescribed, Bio stimulation (Low Level Laser therapy) has been found to provide pain relief. Recently Platelet concentrates have been researched of which injectable form (i-PRF) has been found to be promising. The beneficial effects of bio stimulation and i-PRF have not yet been studied. So, an effort was made to combine both to achieve a successful, non-invasive technique has been reported in this case report. There was improvement in Oral manifestation and Quality of life of the Patient