Natural world has been a resource of curative agents for thousands of year and an inspiring number of modern drug have been isolated from natural sources, many based on their use in traditional medicine. Plants from the genus Zizyphus have been used in conventional medicine by many cultures. Flavonoids, phenolic compounds tri-terpenic acids and polysaccharides constituents have been reported as the major phyto-constituents of the Zizyphus species. This review describes pharmacological reports of the Z. jujube. Various virgin areas of investigate on the Z. jujube have been spotlighted with a sight to explore, isolate and identify the medicinally important phyto-constituents which could be utilized to alleviate diverse diseases distressing the mankind.