Among oral diseases dental caries is a highly prevalent multifactorial disease and has been a major public health problem for many centuries. Several remineralizing agents helps in remineralization to prevent disease progression, and to improve form and function of the teeth. Remineralization is the process of depositing calcium and phosphate ions into crystal voids in demineralized enamel, thus producing net mineral gain. The present article reviews about the various agents that enhance and promote remineralization of tooth structure and their implementation into clinical practice.