Indian system of medicines like Ayurveda, Siddha and Unani utilize large number of medicinal plants for the treatment of various illnesses of mankind. According to WHO 80% of world population depends upon traditional system of medicine. Cissus Quadrangularis is medicinal plant belonging to Family Vitaceae, is commonly known as Veldt Grape or Devil’s Backbone. Popularly known as Hadjod (Bone setter) in Hindi. From ancient times it has been used as curative agent in various diseases particularly for bone healing, digestive aid and cure of piles. Considering its therapeutic value this review has been done to compile information of various researches done on this plant with emphasis on its potential applications in Dentistry.