SARS COV-2 has been stated a pandemic by the World Health Organization as established cases come up to more than 11.200.000 patients with what will exceed 528.000 deaths across over the world. COVID-19 can look dissimilar in different people. For numerous people, being unwell with COVID-19 would be a little bit like having the flu. People can get a fever, cough, or have a hard time taking deep breaths. The majority people who have gotten COVID-19 have not gotten very sick. Merely a small group of people who get it have had more grave problems. Most kids do not show to be at higher risk for COVID-19 than adults. As some children and infants have been sick with COVID-19, adults make up most of the known cases to date. Alterations of clinical manifestation between children and adults infected with SARS COV-2 were attributed to differences in immune response, which is depending on the levels of immuno-modulating agents. Several diagnostic methods were implemented to support the clinical diagnosis, up to date there is no constant protocol to treat SARS COV-2 whether in children or adults, extensive researches are needed to face this pandemic crisis.