Renal neoplasms are one of the most common cancers contributing to significant morbidity and mortality. In patients undergoing nephrectomy for renal neoplasm, the structural integrity and function of contralateral kidney assumes extreme importance. Non-neoplastic renal tissue accompanying the tumour provides an opportunity to recognize non neoplastic pathological changes and to identify patients at risk for progressive renal disease after nephrectomy. The purpose of this study is to evaluate the spectrum of non-neoplastic lesions in tumour nephrectomy specimens. We reviewed the hematoxylin and eosin stained slides of 100 tumour nephrectomy specimens with our emphasis on studying the non-neoplastic renal parenchyma. Our study revealed significant non-neoplastic lesions in 76 of the total 100 specimens evaluated with Diabetic Nephropathy being the most common (36%). Identification of renal non-neoplastic pathology may lead to initiation of medical intervention and can facilitate early preventive and treatment measures ensuring better quality of life for the patient.