Background: The aim of this study is to assess the effectiveness of COVID-19 on quality of life of dentists at health care centers in Saudi Arabia. Material and Methods: This study was conducted for two weeks. Sample was selected randomly and included 300 dentists from different specialty. Questionnaire about demographic data and effect of Covid-19 on quality of life were used. Results: A total of 204 (68%) of dentists who replied was work in government sector. Their average age ranges from 20 years to 50 years and most of the dentist who answered the questionnaire (45%) work for more than 10 years of service. The second part about the effect of the virus on the quality of life most of them (93%) they feel their safety is in risk during working hours. 87% of the participant dentist they had a symptom of depression and anxiety and (70%) of them they worried about being a source of infection for their family. For the dentists who work in private sector (40%) of them afraid from lose their job and facing a financial problem. Conclusion: Regarding to the result we found that COVID-19 pandemic had a negative effect on quality of life for the dentist in both sector the government and private.