Introduction: Coronary artery disease (CAD) is a most common cause of death in developed as well as developing countries. Inflammation plays an important role in the pathogenesis of CAD. Aim and Objective: To identify the hsCRP levels in established CAD patients and its correlation with angiographic severity. Research Design and Methods: A cross sectional study conducted on 72 patients of established CAD aged between 35 and 55 years. The coronary angiographic severity was assessed by number of coronary vessels involved and Gensini scoring system. The serum hsCRP was estimated by Enzyme Linked Immunosorbent Assay. Results: The mean hsCRP level was 14.85 mg/dL. Among the total 72 study participants 33 had single vessel disease, 13 and 25 had double vessel and triple vessel involvement respectively. There was no significant correlation of hsCRP with angiographic finding (r=0.103, p=0.385). Conclusion: We found that hsCRP was highly elevated but not a predictor of angiographic severity among established CAD with presence of other cardiovascular risk factors.