Vitamin D is a fat soluble hormone, with a well explained function in bone fitness and calcium/phosphate metabolism. Current proofs have linked vitamin D to other physiological functions and pathological states. Addition of vitamin D supplements to the theorized (Minocycline, N-acetylcysteine and Aspirin) triple combined therapy to COVID-19, may improve the therapeutic efficacy of the joint therapy. Invivo and invitro laboratory experiments will confirm this theory about COVID-19 crisis.