Introduction: Hyperferritinemia occurs in several medical conditions. The most prevalent underlaying causes are kidney and liver diseases, infections and tumors. The objective of our study was to establish the epidemiological profile of hyperferritinemia among patients consulting cases who attends the Military Hospital Moulay Ismail of Meknes. Materials and methods: In this study, we have enrolled all patients whose blood level of ferritin are above 600µg/l measured on Cobas® 6000 Analyzer, during a period of 12 months. Results: A total of 413 patients had values greater than 600 μg/l, which corresponds to a percentage of 7.37%. The average age was 44 years ± 8 years (18-70). The H/F sex ratio was 1.27. The mean rate of ferritin serum level was 1123 µg/l. Patients with hyperferritinemia were mostly outpatients in 76.7% of cases. Referred patients comes from internal medicine department (9.4%), nephrology (7%), gastrology (3.2%), oncology (2.7%), endocrinology and hematology (2.4%), dermatology (1.9%) and rheumatology (1.2%). The distribution of etiologies was as following: infections (56%), nephropathies (31.5%), systemic diseases (17.5%), liver diseases (15%), diabetes (8.5%), hemopathies (7.5%), hemochromatosis (7%) and neoplasia (5%). More than the half of patients (57%) had multiple causes simultaneously. The most common causes associations in patients with hyperferritinemia were respectively: infections-nephropathies (24%), infections-systemic diseases (14%) and infections-nephropathies-diabetes (6.5%). Discussion and Conclusion: Infections and kidney diseases dominated the etiological spectrum of hyperferritinemia in our population. However, the underlying causes remain various, which makes hyperferritinemia a poor specific marker for disease diagnosis.