Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2). It is affecting 213 countries and territories around the world. The disease causes respiratory illness (like the flu) with symptoms such as a cough, fever, and in more severe cases, difficulty breathing, cardiac problems were also observed in many COVID-19 patients.We theorize that COVID-19 induce mutation in chromosome 4 lead to 4p15.1-pter Duplication and a 4q35.1-qter Deletion , and the neurological and cardiac disorders observed among infected persons resulted from retrotransposition mechanism of gene duplication occur in the specified region of chromosome 4 mentioned above. Genetic studies to chromosome 4 of COVID -19 patients recommended to confirm MOA duplication and deletion theory (4p15.1-pter Duplication and a 4q35.1-qter Deletion).