‘Endodontics’ is the branch of dentistry that deals with the tissues around the pulp and roots of a tooth. The treatment of the soft pulp tissue inside the tooth are included in the Endodontic treatment commonly called as the root canal treatment. The exposure of the pulp caused due to caries or dental trauma may result in bacterial colonization in the pulp tissue resulting in Endodontic infection. The dental procedures like the endodontic treatment (root canal treatment), tooth extraction, root scaling, bilateral tonsillectomy and periodontal surgery may cause Bacteremia and is well documented in the literature. The Bacteremia can cause many fatal problems like Heart valve deformity, Endothelial cell damage to valve, Platelet aggregation on valve, Non-bacterial thrombotic endocarditis (NBTE), Bacterial adherence to NBTE, Bacterial colonization of valve NBTE, Bacterial endocarditis. The main aim of this research was to review the literature related to the relationship between the systemic diseases and endodontics. The principal investigator of this research conducted a systemic comprehensive literature review independently using Web of Science, Scopus, Pubmed Central, Medline, EMBASE, and Cochrane web databases. The 16 articles that followed all the required criteria were selected, studied and evaluated. In the current study, the literature related to the association of chronic systemic disease and endodontic diseases were studied. With this we can conclude that a probable co-relation occurs between the chronic systemic diseases and the endodontic diseases.