Wound healing involves a complex cascade of events, ordered and complex, involving many types of cells, which are driven by the release of soluble mediators and signals able to influence these circulating cells and cause them to home back to damaged tissues. Platelets proved themselves to be an important cells regulating haemostasis phases through the vascular occlusion and facilitating fibrin clot formation. This fibrin scaffold, devoid of any cytotoxic property, is obtained from 9ml of patient’s blood, after centrifugation performed with a centrifuge and the use of gel-free vials; it contains a variety of blood cells- including platelet, B and T lymphocytes, monocytes, stem cells and neutrophilic granulocytes- other than growth factors. L- PRF (leukocyte-PRF) and its derivatives (A-PRF, i- PRF and so on). There is an abundance of literature on the use of injectable PRF (i-PRF) on dental implants with successful results. Therefore, in this case report i-PRF was used as regenerative alloplastic material for an infrabony defect. At 9 months follow-up, there was a reduction in pocket depth and radiographic evidence of bone fill was also noted.