Abstract: Regular blood donation has been reported to lower coronary heart disease risk by improving lipid profiles in past studies. Traditionally, lipid profile estimation assesses an individual’s risk of developing coronary heart disease. This study sought to determine coronary heart disease risk profiles in blood donors, using lipids and to compare risk profiles of first time donors and active donors. Eighty-eight participants were enrolled into the study, 37 (42%) were regular blood donors. Regular blood donors were generally older than first time donors and there was significant difference in LDL levels between the two groups. Differences in both mean age and mean LDL levels of regular blood donors and first time donors could increase risk of coronary heart disease in regular blood donors. Surprisingly, this study was in contrast to earlier studies which reported a decrease in coronary heart disease risk in blood donors and this requires further inquiry.