Abstract: Serum concentrations of total cholesterol (TC), high density lipoprotein (HDL), low density lipoprotein (LDL) have been shown to increase appreciably during pregnancy to meet maternal and fetal metabolic demands. However, this may expose the body to dangers of atherosclerotic plaques. The current study was a transversal study of 99 healthy pregnant women attending the Parirenyatwa Antenatal Clinic and Labour Ward in Zimbabwe and 24 age-matched, healthy, non-pregnant women as controls. Serum samples were collected for estimation of lipids: TC, LDL and HDL were measured and TC/HDL ratio was calculated. According to this Zimbabwean study, normal pregnant women were found to have significant increase in TC, LDL and HDL when compared with normal non-pregnant control group (P<0.001). TC/HDL changed with age of gestation but remained within the normal range. The study concludes that normal pregnancy does not predispose pregnant women to atherogenic lipid profiles most likely due to corresponding increase in HDL that appreciatively lowered TC/HDL ratio during gestation in our setting.